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Amiodarone-induced thyroid dysfunction in a tertiary center in south Brazil
Schaan, Beatriz D; Cunha, Caroline P; Francisconi, Alessandra; Zottis, Berenice; Brum, Graciela; Bruch, Ricardo S; Gus, Miguel.
  • Schaan, Beatriz D; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
  • Cunha, Caroline P; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
  • Francisconi, Alessandra; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
  • Zottis, Berenice; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
  • Brum, Graciela; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
  • Bruch, Ricardo S; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
  • Gus, Miguel; Fundação Universitária de Cardiologia. Instituto de Cardiologia do Rio Grande do Sul. Porto Alegre. BR
Arq. bras. endocrinol. metab ; 49(6): 916-922, dez. 2005. tab
Article in English | LILACS | ID: lil-420163
RESUMO
Amiodarone, used in the treatment of cardiac arrhythmias, is associated with thyroid dysfunction. No reports exist on its frequency in southern Brazil, nor studies evaluating the usefulness of clinical scores to diagnose thyroid abnormalities in these patients. This study aimed at determining the prevalence of amiodarone-induced thyroid dysfunction in a representative sample from a tertiary center, to study the conditions associated to this dysfunction and to evaluate the reliability of clinical scores of hypo and hyperthyroidism. One hundred ninety-five amiodarone users were submitted to a clinical and laboratory evaluation. Of these, 2.1 percent were hyperthyroid, 25.1 percent hypothyroid and 9.2 percent had only a high T4. Considering thyroid dysfunction variables researched, thyroid autoimmunity was positively associated (OR 4.8; p= 0.02), and male gender had a trend to a positive association (OR 1.86; p= 0.06). Clinical scores were highly sensitive for hyperthyroidism (100 percent), but not for hypothyroidism (8 percent). The low prevalence of amiodarone-induced hypothyroidism suggests that this specific region is iodine-sufficient. All patients receiving chronic amiodarone therapy should be checked for clinical scores for hyperthyroidism and laboratory evaluation should be performed, as a screening for thyroid dysfunction, especially if they are male or have positive microsomal antibodies.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Amiodarone / Hyperthyroidism / Hypothyroidism / Anti-Arrhythmia Agents Type of study: Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Universitária de Cardiologia/BR

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Full text: Available Index: LILACS (Americas) Main subject: Amiodarone / Hyperthyroidism / Hypothyroidism / Anti-Arrhythmia Agents Type of study: Risk factors Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Arq. bras. endocrinol. metab Journal subject: Endocrinology / Metabolism Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Universitária de Cardiologia/BR