Contribution of angiotensin-(1-7) to the pathophysiology of hypertension

ABSTRACT

Among the functionally bioactive peptides of the reninangiotensin system, angiotensin-(l-7) is considered the most pleiotropic because it exerts effects that may be similar to, different or opposite from those displayed by Ang II. Ang-(l-7) lacks the pressor, dipsogenic or stimulatory effect on aldosterone release characteristic of Ang II. In contrast, it produces vasodilation, natriuresis and diuresis and inhibits angiogenesis, cell growth and baroreflex control of blood pressure. Taken together, these findings suggest that Ang-(l-7) is an endogenous counterregulator of the pressor and trophic actions of Ang II, playing an important role in the regulation of cardiovascular and renal function and the pathophysiology of hypertension