Sub-lethal injection of honeybee venom decreased the levels of endogenously present substances in organs of mice
J. venom. anim. toxins
;
8(2): 255-268, 2002. graf
Article
in English
| LILACS
| ID: lil-423230
RESUMO
Pharmacological substances such as adenosine deaminase (ADA), collagen, histamine, IgE, myoglobin, and nerve growth factor (NGF) are endogenously present in animals. Research from this laboratory reported decreased levels of ADA, histamine, IgE, and NGF in organs of mice injected with sub-lethal doses of cobra venom. The goal of this research is to observe the levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs of mice injected with venom from the bee Apis mellifera. Adult Balb/c female mice IM injected with half lethal dose of bee venom were sacrificed after 2 and 8 hours for removal of organs. The homogenates of the organs were assayed by ELISA for ADA, collagen, histamine, IgE, myoglobin, and NGF using respective antisera. Organs from mice injected with PBS were used as controls. It was observed that there were decreased levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs after 2 h and tremendous decrease after 8 h. This is the first report showing the pharmacokinetics of ADA, collagen, histamine, IgE, myoglobin, and NGF as consequence of honeybee envenomation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bee Venoms
/
Immunoglobulin E
/
Histamine
/
Adenosine Deaminase
/
Collagen
/
Nerve Growth Factor
/
Myoglobin
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
J. venom. anim. toxins
Journal subject:
Toxicology
Year:
2002
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Ophidia Products Inc./US
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