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Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits
Aguirre, José Ignacio; Gomar, María Soledad; Igal, Silvio; Quiroga, María Alejandra; Portiansky, Enrique Leo; Gimeno, Eduardo Juan.
  • Aguirre, José Ignacio; National University of La Plata. School of Veterinary Sciences. Institute of Pathology 'Prof. Dr. Bernardo Epstein'. La Plata. AR
  • Gomar, María Soledad; National University of La Plata. School of Veterinary Sciences. Institute of Pathology 'Prof. Dr. Bernardo Epstein'. La Plata. AR
  • Igal, Silvio; National University of La Plata. School of Veterinary Sciences. Department of Electron Microscopy. La Plata. AR
  • Quiroga, María Alejandra; National University of La Plata. School of Veterinary Sciences. Institute of Pathology 'Prof. Dr. Bernardo Epstein'. La Plata. AR
  • Portiansky, Enrique Leo; National University of La Plata. School of Veterinary Sciences. Institute of Pathology 'Prof. Dr. Bernardo Epstein'. La Plata. AR
  • Gimeno, Eduardo Juan; National University of La Plata. School of Veterinary Sciences. Institute of Pathology 'Prof. Dr. Bernardo Epstein'. La Plata. AR
Pesqui. vet. bras ; 25(1): 34-38, jan.-mar. 2005. ilus
Article in English | LILACS | ID: lil-423322
ABSTRACT
The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum) (Sm) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions.
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Full text: Available Index: LILACS (Americas) Main subject: Plants, Toxic / Rabbits / Bone and Bones / Solanum Language: English Journal: Pesqui. vet. bras Journal subject: Veterinary Medicine Year: 2005 Type: Article Affiliation country: Argentina Institution/Affiliation country: National University of La Plata/AR

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Full text: Available Index: LILACS (Americas) Main subject: Plants, Toxic / Rabbits / Bone and Bones / Solanum Language: English Journal: Pesqui. vet. bras Journal subject: Veterinary Medicine Year: 2005 Type: Article Affiliation country: Argentina Institution/Affiliation country: National University of La Plata/AR