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Tissue mRNA expression in rat of newly described matrix metalloproteinases
Bernal, Fabian; Hartung, Hans-Peter; Kieseier, Bernd C.
  • Bernal, Fabian; Heinrich-Heine-University. Research Group for Clinical and Experimental Neuroimmunology. Department of Neurology. Düsseldorf. DE
  • Hartung, Hans-Peter; Heinrich-Heine-University. Research Group for Clinical and Experimental Neuroimmunology. Department of Neurology. Düsseldorf. DE
  • Kieseier, Bernd C; Heinrich-Heine-University. Research Group for Clinical and Experimental Neuroimmunology. Department of Neurology. Düsseldorf. DE
Biol. Res ; 38(2/3): 267-271, 2005. tab, graf
Article in English | LILACS | ID: lil-424730
ABSTRACT
Matrix metalloproteinases (MMPs) comprise a large group of endoproteinases that degrade all protein components of the extracellular matrix. Functionally, MMPs contribute to several different physiological as well as pathological conditions. The number of newly described MMPs has increased in recent years, although current knowledge about their expression pattern in various tissues remains incomplete. Here we analyzed the relative mRNA expression of the most recently described MMPs _ MT5-MMP (MMP-24), MT6-MMP (MMP-25), MMP-27 and epilysin (MMP-28) _ in a broad selection of rat tissues using real time-PCR. MMP-24 mRNA was found to be widely expressed with predominance in the central nervous system. MMP-25 mRNA, in contrast, exhibited peak expression levels in testis, kidney and skeletal muscle, differing from previously described distribution patterns in humans. mRNAs for MMP-27 and MMP-28 were generally expressed at a lower level. All four MMPs studied were detected at higher mRNA levels in bone and kidney, suggesting a possible role of these MMPs in physiological processes within these two organs. The present study highlights the differential distribution pattern of newly described MMPs among different tissues and underlines differences in the mRNA expression between different species.
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Full text: Available Index: LILACS (Americas) Main subject: Matrix Metalloproteinases Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2005 Type: Article / Project document Affiliation country: Germany Institution/Affiliation country: Heinrich-Heine-University/DE

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Full text: Available Index: LILACS (Americas) Main subject: Matrix Metalloproteinases Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2005 Type: Article / Project document Affiliation country: Germany Institution/Affiliation country: Heinrich-Heine-University/DE