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Avaliação da doença de Alzheimer através da espectroscopia de prótons por ressonância magnética: comparação entre os achados no cíngulo posterior e nos hipocampos / Evaluation of Alzheimer's disease using magnetic resonance spectroscopy: comparation between findings in the posterior cingulate and hippocampi
São Paulo; s.n; 2005. [154] p. ilus, tab, graf.
Thesis in Portuguese | LILACS | ID: lil-424891
RESUMO
Foi realizada a comparação entre os achados de espectroscopia de prótons por ressonância magnética utilizando a sequência PRESS (point resolved spectroscopy), com TE curto (35ms) no cíngulo posterior e hipocampos de 29 pacientes com doença de Alzheimer (leve e moderada) e 15 controles. As relações de metabólitos com melhor sensibilidade e especificidade na diferenciação entre os grupos foram em ordem decrescente Naa/Cr do cíngulo, mI/Naa do cíngulo, mI/Naa dos hipocampos e mI/Cr dos hipocampos / The objective of this study is to compare the findings on Magnetic Resonance Spectroscopy using PRESS (point resolved spectroscopy) technique with short TE (35ms) in the posterior cingulate and hippocampi of 29 patients with Alzheimer’s disease (mild and moderate) and 15 controls. The metabolic ratios with highest sensitivity and specificity were (in a decreasing order) posterior cingulate Naa/Cr, posterior cingulate mI/Naa, hippocampi mI/Naa and hippocampi mI/Cr. In the group analised it seems there is no advantage in performing MRS in the hippocampi instead of posterior cingulate, a technically challenging location, usually leading to a longer examination time. In the posterior cingulate we observed a positive correlation with Naa/Cr ratio and a negative correlation with mI/Naa ratio and the MMSE...
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Magnetic Resonance Spectroscopy / Alzheimer Disease / Gyrus Cinguli Type of study: Diagnostic study Limits: Female / Humans / Male Language: Portuguese Year: 2005 Type: Thesis

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Full text: Available Index: LILACS (Americas) Main subject: Magnetic Resonance Spectroscopy / Alzheimer Disease / Gyrus Cinguli Type of study: Diagnostic study Limits: Female / Humans / Male Language: Portuguese Year: 2005 Type: Thesis