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Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis
Moreira, M. A; Souza, A. L. S; Lana-Peixoto, M. A; Teixeira, M. M; Teixeira, A. L.
  • Moreira, M. A; Universidade Federal de Minas Gerais. Hospital das Clínicas. Centro de Investigação em Esclerose Múltipla. Belo Horizonte. BR
  • Souza, A. L. S; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunofarmacologia. Belo Horizonte. BR
  • Lana-Peixoto, M. A; Universidade Federal de Minas Gerais. Hospital das Clínicas. Centro de Investigação em Esclerose Múltipla. Belo Horizonte. BR
  • Teixeira, M. M; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Laboratório de Imunofarmacologia. Belo Horizonte. BR
  • Teixeira, A. L; Universidade Federal de Minas Gerais. Hospital das Clínicas. Centro de Investigação em Esclerose Múltipla. Belo Horizonte. BR
Braz. j. med. biol. res ; 39(4): 441-445, Apr. 2006. ilus
Article in English | LILACS | ID: lil-425080
Responsible library: BR1.1
RESUMO
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in inflammatory sites. They are divided into subfamilies on the basis of the location of conserved cysteine residues. We determined the levels of some CC and CXC chemokines in the cerebrospinal fluid (CSF) of 23 relapsing-remitting MS patients under interferon-ß-1a therapy and 16 control subjects using ELISA. MS patients were categorized as having active or stable disease. CXCL10 was significantly increased in the CSF of active MS patients (mean ± SEM, 369.5 ± 69.3 pg/mL) when compared with controls (178.5 ± 29.1 pg/mL, P < 0.05). CSF levels of CCL2 were significantly lower in active MS (144.7 ± 14.4 pg/mL) than in controls (237.1 ± 16.4 pg/mL, P < 0.01). There was no difference in the concentration of CCL2 and CXCL10 between patients with stable MS and controls. CCL5 was not detectable in the CSF of most patients or controls. The qualitative and quantitative differences of chemokines in CSF during relapses of MS suggest that they may be useful as a marker of disease activity and of the mechanisms involved in the pathogenesis of the disease.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Chemokines, CC / Chemokines, CXC / Multiple Sclerosis, Relapsing-Remitting Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR

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Full text: Available Index: LILACS (Americas) Main subject: Chemokines, CC / Chemokines, CXC / Multiple Sclerosis, Relapsing-Remitting Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR