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Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
Zuardi, A. W; Crippa, J. A. S; Hallak, J. E. C; Moreira, F. A; Guimarães, F. S.
  • Zuardi, A. W; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Neurologia, Psiquiatria e Psicologia Médica. Ribeirão Preto. BR
  • Crippa, J. A. S; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Neurologia, Psiquiatria e Psicologia Médica. Ribeirão Preto. BR
  • Hallak, J. E. C; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Neurologia, Psiquiatria e Psicologia Médica. Ribeirão Preto. BR
  • Moreira, F. A; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
  • Guimarães, F. S; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
Braz. j. med. biol. res ; 39(4): 421-429, Apr. 2006. ilus, tab, graf
Article in English | LILACS | ID: lil-425087
RESUMO
A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic and/or antipsychotic actions. Studies in animal models and in healthy volunteers clearly suggest an anxiolytic-like effect of CBD. The antipsychotic-like properties of CBD have been investigated in animal models using behavioral and neurochemical techniques which suggested that CBD has a pharmacological profile similar to that of atypical antipsychotic drugs. The results of two studies on healthy volunteers using perception of binocular depth inversion and ketamine-induced psychotic symptoms supported the proposal of the antipsychotic-like properties of CBD. In addition, open case reports of schizophrenic patients treated with CBD and a preliminary report of a controlled clinical trial comparing CBD with an atypical antipsychotic drug have confirmed that this cannabinoid can be a safe and well-tolerated alternative treatment for schizophrenia. Future studies of CBD in other psychotic conditions such as bipolar disorder and comparative studies of its antipsychotic effects with those produced by clozapine in schizophrenic patients are clearly indicated.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Schizophrenia / Antipsychotic Agents / Anti-Anxiety Agents / Cannabidiol / Cannabis Type of study: Controlled clinical trial / Diagnostic study Limits: Animals / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Schizophrenia / Antipsychotic Agents / Anti-Anxiety Agents / Cannabidiol / Cannabis Type of study: Controlled clinical trial / Diagnostic study Limits: Animals / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR