Sensibilidad a IGF-I en niños pequeños para la edad gestacional / IGF-I sensitivity in small for gestational age children
Rev. méd. Chile
; 134(1): 21-30, ene. 2006. ilus, tab, graf
Article
in Es
| LILACS
| ID: lil-426114
Responsible library:
BR1.1
RESUMO
Background:
The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I).Aim:
To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of growth hormone (GH). Patients andmethods:
We studied 34 prepubertal SGA children aged 4 to 11 years. Twenty three had CUG and 11 did not have CUG. As an IGF-I sensitivity test, nocturnal GH levels were measured every 20 minutes from 2300 h to 0700 h, both under baseline conditions and after the administration of a subcutaneous bolus of 1 mg/kg/body weight of the IGF-I + IGFBP-3 complex (Somatokine®).Results:
At the time of the study, the Z scores for height among children with and without CUG were -1.55 ± 0.22 and -3.24 ± 0.28, respectively (p <0.0001). There were no statistical differences between CUG + vs CUG- patients in mean basal GH (6.6 ± 0.5 and 5.6 ± 0.6 ng/ml, respectively). After Somatokine® administration, mean GH, and the mean GH area under the curve (AUC) decreased significantly in both groups. However, mean overnight GH AUC decreased in all SGA children with CUG, after Somatokine® administration, whereas 3 out of 11 SGA children without CUG had an increase in their mean GH AUC in response to Somatokine®.Conclusions:
These findings suggest that pituitary sensitivity to IGF-I may be decreased in some SGA children without CUG.
Full text:
1
Index:
LILACS
Main subject:
Recombinant Fusion Proteins
/
Infant, Small for Gestational Age
/
Insulin-Like Growth Factor I
/
Growth Hormone
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
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Male
/
Newborn
/
Pregnancy
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2006
Type:
Article
/
Congress and conference
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Project document