Fos-like immunoreactivity in central nervous system of mice simultaneously exposed to the elevated plus-maze and nociception
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
41(3): 385-391, jul.-set.2005. ilus, graf
Article
in English
| LILACS
| ID: lil-427934
ABSTRACT
It has been demonstrated that mice exhibit antinociception when they are exposed to the elevated plus-maze (EPM), an animal model of anxiety. To investigate which brain structures are activated during EPM exposure, the present study assessed the immunohistochemical staining for Fos-like immunoreactivity (Fos-LI) in mice intraperitoneally injected with saline or 0,6 por cente acetic acid (which produces nociception) and cofined in the open arm (threatening situation) or enclosed arm (Control) of the EPM. The following strutuctures were investigated magnus, dorsal and median raphe nuclei (MR, DR and MnR), periaqueductal gray matter (PAG), dorsal and ventral hippocampus (DH and VH), amygdala (AMY), hypothalamus (HYP) and superior and inferior colliculi (SC and IC)...
Full text:
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Index:
LILACS (Americas)
Main subject:
Pain Measurement
/
Central Nervous System
/
Genes, fos
/
Maze Learning
/
Fear
/
Animals, Laboratory
Limits:
Animals
Language:
English
Journal:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Journal subject:
Biochemistry
/
Pharmacy
/
Pharmacology
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual Paulista/BR
/
Universidade de São Paulo/BR
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