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Effect of the essential oil of Achillea millefolium L. in the production of hydrogen peroxide and tumor necrosis factor-"ALPHA" in murine macrophages
Lopes, Flávia Cristine Mascia; Benzatti, Fernanda Paulin; Jordão Junior, Cleso Mendonça; Moreira, Raquel Regina Duarte; Carlos, Iracilda Zeppone.
  • Lopes, Flávia Cristine Mascia; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas. Araraquara. BR
  • Benzatti, Fernanda Paulin; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas. Araraquara. BR
  • Jordão Junior, Cleso Mendonça; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Ciências Biológicas. Araraquara. BR
  • Moreira, Raquel Regina Duarte; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Princípios Ativos Naturais e Toxicologia. Araraquara. BR
  • Carlos, Iracilda Zeppone; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas. Araraquara. BR
RBCF, Rev. bras. ciênc. farm. (Impr.) ; 41(3): 401-405, jul.-set.2005. tab, graf
Article in English | LILACS | ID: lil-427936
RESUMO
Macrophages release more than one hundred compounds into the extracellular environment. Among these, there are cytokines and intermediate oxigen compounds, such as TNF-"ALPHA" and 'H POT. 2''O POT. 2'. We evaluated the effect of the crude essential oil of Achillea millefolium L. (Asteraceae) by determining hydrogen peroxide ('H POT. 2''O POT. 2') and tumor necrosis factor-a (TNF-"ALPHA") release in cultures of peritoneal macrophages cells from Swiss mice. Commercial azulene was also tested for comparison with the essential oil. The macrophages viability in the presence of the oil was analyzed and dilutions of 1100 and 1200 showed the best results. A mild production of 'H POT. 2''O POT. 2' and a moderate liberation of TNF-"ALPHA" were observed...
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Full text: Available Index: LILACS (Americas) Main subject: Oils, Volatile / Millefolium / Tumor Necrosis Factor-alpha / Macrophages, Peritoneal / Hydrogen Peroxide Limits: Animals Language: English Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: Biochemistry / Pharmacy / Pharmacology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Oils, Volatile / Millefolium / Tumor Necrosis Factor-alpha / Macrophages, Peritoneal / Hydrogen Peroxide Limits: Animals Language: English Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: Biochemistry / Pharmacy / Pharmacology Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR