Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia / Primary biliary cirrhosis: a thirteen years experience
Rev. méd. Chile
;
134(4): 469-474, abr. 2006. tab
Article
in Spanish
| LILACS
| ID: lil-428547
RESUMO
Background:
Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure.Aim:
To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material andmethods:
Retrospective review of medical records of 115 patients (110 females, age range 30-76 years) with PBC. Clinical presentation, pathological stage, treatment, outcome and eventual use of liver transplantation, were recorded.Result:
Seventy eight percent of patients were symptomatic at presentation (itching in 69% and malaise in 62%). Antimitochondrial antibodies were positive in 56%. No clinical or laboratory differences were observed between symptomatic patients or those with positive antimitochondrial antibodies and the rest of the study group. Sjögren syndrome was present in 38%, hypothyroidism in 13%, scleroderma in 7% and rheumatoid arthritis in 5%. Initially, 61% had fibrosis and/or cirrhosis, and ursodeoxycholic acid was indicated in 94% of the patients. Fifteen patients underwent liver transplantation due to upper digestive bleeding or itching. Survival has been 67% at 36 months after transplantation. In one transplanted liver, PBC recurred.Conclusions:
An early diagnosis and treatment of a progressive disease such as PBC will reduce the incidence of complications and the use of costly treatments.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Liver Cirrhosis, Biliary
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2006
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Las Condes/CL
/
Universidad de Chile/CL
Similar
MEDLINE
...
LILACS
LIS