A new nomogram to predict pathologic outcome following radical prostatectomy
Int. braz. j. urol
;
32(2): 155-164, Mar.-Apr. 2006. tab
Article
in English
| LILACS
| ID: lil-429027
ABSTRACT
OBJECTIVE:
To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS ANDMETHODS:
Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement.RESULTS:
In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87 percent and 91.1 percent of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10 percent respectively.CONCLUSION:
Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Prostate-Specific Antigen
/
Nomograms
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2006
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Sao Paulo/BR
Similar
MEDLINE
...
LILACS
LIS