Anti-VHE IgM en casos de infección por el virus hepatitis E / Detection of IgM antibodies against hepatitis E virus
Rev. méd. Chile
;
133(6): 645-647, jun. 2005. tab
Article
in Spanish
| LILACS
| ID: lil-429117
ABSTRACT
Background:
Hepatitis E virus is the main enterically transmitted non A non B hepatitis agent. The host IgM response in the acute infection phase is short lived. Therefore, only IgG antibodies against E virus are usually investigated.Aim:
To measure IgM antibodies against virus E in serum samples. Material andMethods:
IgM antibodies against virus E were measured by ELISA in 35 positive and 18 negative serum samples for IgG antibodies against hepatitis virus E, without evidence of infection with hepatitis A, B or C virus. Measurement of the same antibodies in 25 additional samples positive for IgM antibodies against hepatitis A virus but without study for hepatitis virus B or C.Results:
IgM antibodies against virus E were detected in 12 of the 35 samples positive for IgG antibodies (34%) and in five of the 25 samples positive for antibodies against virus A (20%).Conclusions:
An acute hepatitis E virus infection was detected in 34% of samples positive for IgG antibodies against this virus. The absence of IgM antibodies in the rest of the IgG positive samples could be due to an old or a recent virus E infection in the stage of antibody titer reduction. The detection of IgM antibodies against virus E in samples positive for virus A antibodies, could be due to co infection by virus A and E or a cross reaction of assays.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunoglobulin M
/
Hepatitis Antibodies
/
Hepatitis E virus
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2005
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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