Antioxidant responses of cortex neurons to iron loading
Biol. Res
;
39(1): 103-104, 2006. ilus
Article
in English
| LILACS
| ID: lil-430703
ABSTRACT
Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. In this work, in cortical neurons we characterized viability and changes in reduced and oxidized glutathione levels in response to a protocol of iron accumulation. We found that massive death occurred after 2 days in culture with 10 mM Fe. Surviving cells developed an adaptative response that included increased synthesis of GSH and the maintenance of a glutathione-based reduction potential. These results highlight the fundamental role of glutathione homeostasis in the antioxidant response and provide novel insights into the adaptative mechanisms of neurons subjected to progressive iron loads.
Full text:
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Index:
LILACS (Americas)
Main subject:
Cerebral Cortex
/
Oxidative Stress
/
Glutathione
/
Iron
/
Neurons
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2006
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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