A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
42(1): 69-76, jan.-mar. 2006. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-431424
RESUMO
Carboxymethylcellulose (CMC)/chitosan microparticles containing vitamin E were prepared by a complex coacervation method and their potential use as a topical delivery system was evaluated. Morphology, particle size distribution, encapsulation yield, physical and chemical stability, in vitro release and permeation through skin were studied. The microparticles appeared to be spherical, with a homogeneous surface and were not aggregated. Mean diameters ranged from 2.7 to 7.6 µm and the encapsulation yield was 81 percent. Chemical stability studies indicated a protection of encapsulated vitamin E, of 8.1 percent for O/W and of 10.83 percent for W/O emulsions, following storage at 45 °C for 60 days. Forty-eight percent of vitamin E, determined by HPLC, were released within 24 hours. In vitro permeation and retention studies showed a higher penetration rate of vitamin E in the free and encapsulated forms, from the W/O emulsion. The carriers studied seem to be promising systems for topical administration.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitamin E
/
Chitosan
/
Drug Stability
Language:
English
Journal:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Journal subject:
Biochemistry
/
Pharmacy
/
Pharmacology
Year:
2006
Type:
Article
Affiliation country:
Brazil
/
Spain
Institution/Affiliation country:
Polígono Industrial San Vicente/ES
/
Universidade de São Paulo/BR
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