Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro
Mem. Inst. Oswaldo Cruz
;
101(3): 341-344, May 2006.
Article
in English
| LILACS
| ID: lil-431738
ABSTRACT
There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P. falciparum strains to AQ and N-desethylamodiaquine is used to illustrate the need to standardized methodologies and compare inhibitory concentrations, instead of resistant/susceptible phenotypes, when studying the mechanisms of resistance to AQ and monitoring drug susceptibility trends in the field.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Aminoquinolines
/
Amodiaquine
/
Antimalarials
Limits:
Animals
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2006
Type:
Article
/
Project document
Affiliation country:
Colombia
Institution/Affiliation country:
International Center for Medical Research and Training/CO
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