Does mycophenolate mofetil increase the risk of cytomegalovirus infection in solid organ transplant recipients? - A mini-review
Braz. j. infect. dis
;
10(2): 132-138, Apr. 2006. tab
Article
in English
| LILACS
| ID: lil-431986
ABSTRACT
Mycophenolate mofetil (MMF) is currently used for prophylaxis of acute rejection in solid organ transplantation. There have been diverging reports regarding an association between MMF and the risk of cytomegalovirus (CMV) infection. We reviewed the main published studies in an attempt to clarify the association between the use of MMF and the risk, frequency and severity of CMV infections. In a search of the Medline database with the terms "mycophenolate" and "cytomegalovir*", 42 articles were found to be relevant; among these, 29 articles were thoroughly analyzed. The first studies on MMF in renal transplantation already showed a tendency towards an association between this drug and the occurrence of CMV disease. Further studies were designed specifically to study this association; with the conclusion that an immunosuppressive regimen containing MMF increases the likelihood of CMV disease. Most studies were performed with kidney transplant recipients. We conclude that the use of MMF apparently increases the incidence of CMV disease in renal transplant patients; however, further studies are needed to confirm this association.
Full text:
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Index:
LILACS (Americas)
Main subject:
Kidney Transplantation
/
Liver Transplantation
/
Cytomegalovirus Infections
/
Immunosuppressive Agents
/
Mycophenolic Acid
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2006
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of São Paulo/BR
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