Diphtheria-neutralizing antibody levels in healthy adults from Rio de Janeiro, Brazil
Mem. Inst. Oswaldo Cruz
;
101(4): 459-462, June 2006. tab
Article
in English
| LILACS
| ID: lil-435310
ABSTRACT
In Brazil, until 2004, the immunization policy against diphtheria involved childhood vaccination with no official routine booster dose administered after 15 years of age. This study assessed functional antibody levels against diphtheria among blood donors. A total of 140 blood samples were collected, and diphtheria antitoxin levels were evaluated by Vero cell neutralization test. The mean age of the population was 34 years old (range 18-61 years); 37.8 percent females and 62.2 percent males. Overall, 30.7 percent (95 percent, CI 23.4-38.7) individuals presented neutralizing antitoxin antibody titers < 0.01 IU/ml; 42.1 percent (95 percent, CI 34.1-50.4) showed values between 0.01-0.09 IU/ml and, 27.1 percent (95 percent, CI 20.2-34.9) had ³ 0.1 IU/ml. In the subgroup of individuals with history of diphtheria immunization during childhood (85 percent), a number of 28.5 percent showed unprotective levels of circulating neutralizing antibody (< 0.01 IU/ml). Despite the continuous progress of immunization programs directed to Brazilian population, currently healthy adults remain susceptible to diphtheria.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Diphtheria Toxoid
/
Corynebacterium diphtheriae
/
Diphtheria
/
Antibodies, Bacterial
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2006
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Secretaria Estadual de Saúde/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade do Estado do Rio de Janeiro/BR
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