Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
Biol. Res
;
37(4): 539-552, 2004. graf
Article
in English
| LILACS
| ID: lil-437507
ABSTRACT
Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.
Full text:
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Index:
LILACS (Americas)
Main subject:
Calcium
/
Muscle, Skeletal
/
Ryanodine Receptor Calcium Release Channel
/
Cerebrum
/
Myocardium
/
Neurons
Limits:
Animals
/
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2004
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico de la Universidad de Chile/CL
/
Universidad de Chile/CL
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