IP3 receptors and Ca2+ signals in adult skeletal muscle satellite cells in situ
Biol. Res
;
37(4): 635-639, 2004. ilus
Article
in English
| LILACS
| ID: lil-437519
ABSTRACT
In this short article we review muscle satellite cell characteristics and our studies in adult rodent muscle satellite cells in situ. Using confocal laser scanning microscopy and immunocytochemistry, a high level of IP3 receptor (IP3R) immunostaining was detected in satellite cells. These cells were identified by their peripheral position, their size, the shape of their nucleus, the paucity of the apparent cytoplasm, and the immunostaining with specific molecular markers such as a-actinin, the neural cell adhesion molecule (N-CAM) and desmin. High extracellular K+ (60 mM) induced long-lasting Ca2+ signals in satellite cells in situ. We suggest that electrical activity stimulates IP3-associated Ca2+ signals that could act in concert with signaling pathways triggered by growth factors and/or hormones.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Calcium Channels
/
Receptors, Cytoplasmic and Nuclear
/
Calcium Signaling
/
Satellite Cells, Skeletal Muscle
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2004
Type:
Article
Affiliation country:
Chile
/
France
/
United States
Institution/Affiliation country:
Institut Fédératif de Neurobiologie Alfredt Fessard/FR
/
Smith College/US
/
Universidad de Chile/CL
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