Expresión inmunohistoquímica del complejo E-caderina-catenina en cáncer gástrico: Relación con variables clínico-morfológicas y sobrevida de pacientes / Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer
Rev. méd. Chile
;
134(8): 1002-1009, ago. 2006. ilus, tab
Article
in Spanish, English
| LILACS
| ID: lil-438371
ABSTRACT
Background:
The E-cadherin/catenin complex plays an essential role in the control of epithelial differentiation. Abnormal expression in tumors correlates with histological grade, advanced stage and poor prognosis.Aim:
To evaluate the expression pattern of E-cadherin/catenin complex in gastric carcinoma and analyze their association with tumor clinicopathological features and patient survival. Material andMethods:
Inmunohistochemical staining of E-cadherin, alpha and ß-catenin was performed from paraffin specimens of 65 gastric carcinomas.Results:
Abnormal expression of E-cadherin, alpha and ß-catenin was demonstrated in 82 percent, 85 percent and 88 percent of gastric carcinomas, respectively. There was a significant correlation between abnormal expression and Lauren pathological classification and depth of infiltration, but not with tumor stage, positive lymph node metastases and survival.Conclusion:
Abnormal expression of E-cadherin, alpha and ß-catenin occurs frequently in gastric carcinoma and correlates with histological grade.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stomach Neoplasms
/
Cadherins
/
Beta Catenin
/
Alpha Catenin
/
Neoplasm Proteins
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
English
/
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2006
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de La Frontera/CL
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