Comparação das contagens das células de Langerhans de tecidos contendo carcinoma anal em doentes com e sem infecção pelo HIV / Comparison of Langerhans cells counts from tissues containing anal carcinoma of patients with and without HIV infection
Rev. bras. colo-proctol
;
26(3): 269-274, jul.-set. 2006. tab
Article
in Portuguese, English
| LILACS
| ID: lil-439161
RESUMO
INTRODUÇÃO:
As células de Langerhans (LC) são derivadas da medula óssea e constituem-se nas principais apresentadoras de antígeno da pele.conferindo desta forma, a resposta imune cutânea. Seu número está reduzido nos imunodeprimidos, incluindo na infecção pelo HIV, e a presença do tumor inibe sua migração, impedindo que os linfócitos T promovam regressão das células neoplásicas.OBJETIVO:
Conhecer as diferenças entre as contagens de LC no tecido tumoral de doentes de carcinomas anais com e sem AIDS.MÉTODO:
Avaliamos 24 doentes, sendo 14 com HIV e 10 outros sem HIV . O tratamento para o carcinoma foi semelhante nos dois grupos. Cortes retirados de blocos parafinados submetidos ao teste imunoistoquímico com anticorpo anti-CD68. Contamos as LC com método da histometria e os comparamos aos números obtidos com amostras previamente conhecidas de doentes sem doença infecciosa anorretal ou infecção pelo HIV. Revisamos também a evolução e as contagens séricas de linfócitos T CD4+ de doentes HIV-positivos.RESULTADOS:
Observamos que o carcinoma anal foi mais freqüente em mulheres HIV-negativas e em homens HIV-positivos e que esses ultimos eram mais jovens. As LC foram menos numerosas nos doentes HIV-positivos e as maiores contagens estavam associadas com pior evolução. Os doentes HIV-positivos com os níveis mais baixos de linfócitos T CD4+ também tiveram as piores evoluções.CONCLUSÃO:
Concluímos que as LC estavam diminuídas nos doentes HIV-positivos, portadores de carcinoma anal, quando comparados aos soronegativos.ABSTRACT
Langerhans cells (LC) are bone marrow derived dendritic cells that represent the major antigen-presenting cells (APC) in the skin, thus representing an integral part of the cutaneous immune response. Immunossupression decreases their number, including HIV infection, and skin tumors products are sufficient to immobilize LC within the tumor, preventing their migration to lymph nodes. This reduces the number of T cells that infiltrate the tumor, preventing regression. OBJETIVE Our proposal was to know what are the differences among LC counts comparing HIV-positive and -negative patients with anal carcinoma. METHOD:
We evaluated 24 patients, 14 with HIV and 10 HIV-negative. Treatment for carcinoma was similar in both groups. Paraffin blocks containing biopsies were cut and stained with antibody anti-CD68. LC were counted in a histometrical way and number were compared to previous known specimens of HIV-negative patients without infectious anorectal diseases. We also studied cancer evolution and T CD4+ lymphocytes blood counts of HIV-positive patients.RESULTS:
Statistics showed that anal carcinomas were more frequent in females HIV-negative and in seropositive males. HIV-positive patients were younger than seronegative ones. LC were decreased in seropositive patients and the most numerous counts were associated to worse prognosis. HIV-positive patients who had the most decreased T CD4+ counts had the worst prognosis, too.CONCLUSION:
We conclude that LC were decreased in HIV-positive patients with anal carcinoma rather than in seronegative.
Full text:
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Index:
LILACS (Americas)
Main subject:
Anal Canal
/
Carcinoma
/
HIV Infections
/
Langerhans Cells
/
Risk Factors
/
Acquired Immunodeficiency Syndrome
/
Papillomavirus Infections
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
Rev. bras. colo-proctol
Journal subject:
Gastroenterology
Year:
2006
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto de Infectologia Emílio Ribas/BR
/
Santa Casa de São Paulo/BR
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