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Presencia de autoanticuerpos anti-SSA/Ro y/o anti-SSB/La y su rol en la progresión hacia enfermedad autoinmune / Presence of autoantibodies anti-SSA/Ro and/or anti-SSB/La and its role in the progression of autoimmune diseases
Rivera V., Tania L; Buyon, Jill P.
  • Rivera V., Tania L; New York University Hospital for joint diseases. Departamento de Reumatología. CL
  • Buyon, Jill P; New York University Hospital for joint diseases. Departamento de Reumatología. CL
Rev. chil. reumatol ; 22(2): 61-66, 2006. tab
Article in Spanish | LILACS | ID: lil-439429
ABSTRACT

Introduction:

The presence of autoantibodies can occur years before clinical disease though their presence does not predict disease progression. Mothers enrolled in The Research Registry for Neonatal Lupus (RRNL) are an excellent opportunity to study disease progression, since all of these women are anti-Ro/La positive, and many are asymptomatic at the birth of an affected child. Materials and

Methods:

99 mothers (32 percent) from the RRNL were studied, all of whom had been follow-up more than on year. They were classified in six different categories depending on the diagnosis made at the time of birth (Asymptomatic, Pauci-SLE, Pauci-SS, SS, SLE and SLE with secondary SS). The presence of the autoantibodies was confirmed by ELISA and Immunoblot assays.

Results:

28.3 percent were asymptomatic at the time of birth, and 39.4 percent had already developed a few symptoms. Out of 67 mothers, 43.3 percent progressed to a clinical autoimmune disease after 8.3 years of follow-up. The most common progression of all the asymptomatic or pauci symptomatic mothers (n = 67) was towards SS (28.4 percent) after a follow-up of 5.4 years, and only 14.9 percent progressed to LES. The latter was seen later in time (8.7 years since birth). Antibody profile was neither useful as a progression biomarker nor as a diagnostic tool.
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Index: LILACS (Americas) Main subject: Autoantibodies / Lupus Erythematosus, Systemic Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans Country/Region as subject: North America Language: Spanish Journal: Rev. chil. reumatol Journal subject: Rheumatology Year: 2006 Type: Article Affiliation country: Chile Institution/Affiliation country: New York University Hospital for joint diseases/CL

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Index: LILACS (Americas) Main subject: Autoantibodies / Lupus Erythematosus, Systemic Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans Country/Region as subject: North America Language: Spanish Journal: Rev. chil. reumatol Journal subject: Rheumatology Year: 2006 Type: Article Affiliation country: Chile Institution/Affiliation country: New York University Hospital for joint diseases/CL