Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda / Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia
Rev. méd. Chile
;
134(11): 1367-1376, nov. 2006. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-439933
ABSTRACT
Background:
t(12;21) (p12;q22) and t(9;22) (q34;q11) translocations have prognostic significance in acute lymphoblastic leukemia (ALL). The fusion genes TEL/AML1 y BCR/ABL, generated by these translocations, can be easily detected using molecular biology technique.Aim:
To study the frequency of TEL/AML1 y BCR/ABL fusion genes in children with ALL. Material andmethods:
Fifity six children with ALL (age range 1 month- 14 years) were studied, thirty eight from our Temuco Hospital and 18 from the Metropolitan Region. TEL/AML1 y BCR/ABL fusion genes were detected in bone marrow samples using a reverse transcriptase nested polymerase chain reaction (RT-PCR).Results:
TEL/AML 1 and BCR/ABL fusion gene transcripts were detected in 13 (23 percent) and 2 (4 percent) children, respectively. No differences in survival were observed between children with positive or negative transcripts for TEL/AML1 fusion gene. However, those positive for BCR/ABL fusion gene, had a significantly lower survival.Conclusions:
The frequency of TEL/AML1 and BCR/ABL fusion gene transcripts in these children with ALL is similar to that described by other authors.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Translocation, Genetic
/
Oncogene Proteins, Fusion
/
Fusion Proteins, bcr-abl
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2006
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Alemana de Temuco/CL
/
Hospital Luis Calvo Mackenna/CL
/
Hospital del Salvador/CL
/
Universidad de La Frontera/CL
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