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Síndrome de McLeod: compromiso multisistémico asociado a neuroacantocitosis ligada al cromosoma X, en una familia chilena / McLeod syndrome: Multisystem involvement associated with neuroacanthocytosis linked to X chromosome. Report of two related cases
Miranda C., Marcelo; Castiglioni T., Claudia; Regonesi L., Carlos; Aravena A., Pedro; Villagra M., Lorena; Quiroz M., Ana; Merino G., Rogelio; Mena G., Ismael.
  • Miranda C., Marcelo; Clínica Las Condes. Unidad de Neurología Adulto. Santiago. CL
  • Castiglioni T., Claudia; Clínica Las Condes. Unidad de Neurología Infantil. Santiago. CL
  • Regonesi L., Carlos; Clínica Las Condes. Laboratorio de Hematología. Santiago. CL
  • Aravena A., Pedro; s.af
  • Villagra M., Lorena; s.af
  • Quiroz M., Ana; s.af
  • Merino G., Rogelio; s.af
  • Mena G., Ismael; Clínica Las Condes. Unidad de Medicina Nuclear. Santiago. CL
Rev. méd. Chile ; 134(11): 1436-1442, nov. 2006. ilus
Article in Spanish | LILACS | ID: lil-439944
ABSTRACT
Neurological abnormalities associated with spiculated, "acanthocytic" red cells in blood have been described as neuroacanthocytosis. This is a heterogeneous group of conditions that can be clearly subdivided on the basis of recent genetic findings. The McLeod Syndrome, one of the core neuroacanthocytosis syndromes, is a rare X-linked disorder caused by mutations of the XK gene, an X-chromosomal gene of unknown function characterized by haemopoietic abnormalities and late-onset neurological and muscular defects. We report two Chilean brothers with the McLeod phenotype who showed important psychiatric features. The diagnosis may be elusive if the presence of acanthocytosis is not properly studied. We describe a method which allowed the diagnosis that unmasked acanthocytosis. Otherwise the condition could have remained undiagnosed as it had been for decades in this family. This syndrome must be considered when assessing a familial movement disorder, specially affecting males with relevant psychiatric features. A reliable test for acanthocytosis assessment is available.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Blood Proteins / Amino Acid Transport Systems, Neutral / Genetic Diseases, X-Linked / Neuroacanthocytosis / Mutation / Antigens, Surface Type of study: Diagnostic study / Risk factors Limits: Humans / Male Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2006 Type: Article Affiliation country: Chile Institution/Affiliation country: Clínica Las Condes/CL

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Full text: Available Index: LILACS (Americas) Main subject: Blood Proteins / Amino Acid Transport Systems, Neutral / Genetic Diseases, X-Linked / Neuroacanthocytosis / Mutation / Antigens, Surface Type of study: Diagnostic study / Risk factors Limits: Humans / Male Country/Region as subject: South America / Chile Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2006 Type: Article Affiliation country: Chile Institution/Affiliation country: Clínica Las Condes/CL