Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
Mem. Inst. Oswaldo Cruz
;
101(8): 895-898, Dec. 2006. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-440578
ABSTRACT
Capillaria hepatica causes two main lesions in the liver of rats multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Capillaria
/
Antibodies, Helminth
/
Enoplida Infections
/
Liver Cirrhosis, Experimental
/
Antigens, Helminth
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2006
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Escola Bahiana de Medicina/BR
/
Fundacao Oswaldo Cruz/BR
/
Universidade Federal da Bahia/BR
Similar
MEDLINE
...
LILACS
LIS