The influence of parental origin of X chromosome genes on the stature of patients with 45 X Turner syndrome
Genet. mol. res. (Online)
;
6(1): 1-7, 2007. tab
Article
in English
| LILACS
| ID: lil-440615
ABSTRACT
Thirty-seven 45 X Turner syndrome patients with confirmed peripheral blood lymphocyte karyotype were initially selected to determine the origin of the retained X chromosome and to correlate it with their parents stature. Blood samples were available in 25 families. The parental origin of the X chromosome was determined in 24 informativefamilies through the analysis of the exon 1 - CAG repeat variation of the androgen receptor gene. In 70.8% of the cases, the retained X chromosome was maternal in origin and 29.2% was paternal. When we classified the patients according to maternal (Xm) or paternal (Xp) X chromosome, there was a positive correlation between patients and maternal heights only in the Xm group. There was no correlation with paternal height in either group, and a significant correlation with target height was only observed in the Xm group. In conclusion, maternal height is the best variable correlating with the height of 45 X Turner syndrome patients who retain the maternal X chromosome, suggesting a strong influence of genes located on the maternal X chromosome on stature.
Full text:
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Index:
LILACS (Americas)
Main subject:
Parents
/
Turner Syndrome
/
Body Height
/
Chromosomes, Human, X
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Ciências Médicas/BR
/
Santa Casa de São Paulo/BR
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