Characterization of the gene expression related to the process of DNA damage tolerance in Schistosoma mansoni
Mem. Inst. Oswaldo Cruz
;
101(supl.1): 157-160, Oct. 2006. ilus
Article
in English
| LILACS
| ID: lil-441241
ABSTRACT
In the course of its complex life cycle, the parasite Schistosoma mansoni need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents. The Schistosoma genome sequencing initiative has uncovered sequences from genes and transcripts related to the process of DNA damage tolerance as the enzymes UBC13, MMS2, and RAD6. In the present work, we evaluate the importance of this process in different stages of the life cycle of this parasite. The importance is evidenced by expression and phylogenetic profiles, which show the conservation of this pathway from protozoa to mammalians on evolution.
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Index:
LILACS (Americas)
Main subject:
Schistosoma mansoni
/
DNA Damage
/
DNA, Helminth
/
Ubiquitin-Conjugating Enzymes
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2006
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Uberlândia/BR
/
Universidade de São Paulo/BR
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