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HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
Melo, Nadja Rodrigues de; Vilela, Maria Marluce Santos; Jorge Junior, Jacks; Kamei, Katsuhiko; Miyaji, Makoto; Fukushima, Kazutaka; Nishimura, Kazuko; Groeneveld, Philip; Kelly, Steven L; Taguchi, Hideaki.
  • Melo, Nadja Rodrigues de; University of Wales Swansea. School of Medicine. Swansea Clinical School. Swansea. GB
  • Vilela, Maria Marluce Santos; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Jorge Junior, Jacks; Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba. Piracicaba. BR
  • Kamei, Katsuhiko; Chiba University. Research Center for Pathogenic Fungi and Microbial Toxicoses. Chiba. JP
  • Miyaji, Makoto; Chiba University. Research Center for Pathogenic Fungi and Microbial Toxicoses. Chiba. JP
  • Fukushima, Kazutaka; Chiba University. Research Center for Pathogenic Fungi and Microbial Toxicoses. Chiba. JP
  • Nishimura, Kazuko; Chiba University. Research Center for Pathogenic Fungi and Microbial Toxicoses. Chiba. JP
  • Groeneveld, Philip; University of Wales Swansea. School of Medicine. Swansea Clinical School. Swansea. GB
  • Kelly, Steven L; University of Wales Swansea. School of Medicine. Swansea Clinical School. Swansea. GB
  • Taguchi, Hideaki; Chiba University. Research Center for Pathogenic Fungi and Microbial Toxicoses. Chiba. JP
Braz. j. microbiol ; 37(3): 225-229, July-Sept. 2006. ilus, graf
Article in English | LILACS | ID: lil-442122
ABSTRACT
Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy (HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mum/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.
RESUMO
O declínio na incidência de candidose orofaríngea e infecções oportunistas associadas a infecção pelo HIV tem sido atribuído a introdução da terapia antiretroviral combinada (HAART). Infecção por C. albicans envolve aderência e colonização da mucosa superficial. Durante este processo leveduras são capazes de transformar-se na forma de hifas e penetrar nos tecidos mais profundos. Usando o sistema "Bio-Cell Tracer", o crescimento de hifas de C. albicans foi observado dinamicamente a nível celular. Ritonavir, inibidor de protease do HIV, foi efetivo na inibição do crescimento de hifas com media de 0.8 mim/min.O presente estudo demonstrou o efeito in vitro de um agente anti-retroviral HIV sobre o crescimento de hifas de C. albicans.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: In Vitro Techniques / Candida albicans / HIV Protease Inhibitors / AIDS-Related Opportunistic Infections / Hyphae Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2006 Type: Article Affiliation country: Brazil / Japan / United kingdom Institution/Affiliation country: Chiba University/JP / Universidade Estadual de Campinas/BR / University of Wales Swansea/GB

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Full text: Available Index: LILACS (Americas) Main subject: In Vitro Techniques / Candida albicans / HIV Protease Inhibitors / AIDS-Related Opportunistic Infections / Hyphae Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2006 Type: Article Affiliation country: Brazil / Japan / United kingdom Institution/Affiliation country: Chiba University/JP / Universidade Estadual de Campinas/BR / University of Wales Swansea/GB