Looking Beyond Tobacco and Alcohol: The Role of Lifestyle and Other Environmental Risk Factors for Laryngeal Cancer
Appl. cancer res
;
25(1): 10-19, Jan.-Mar. 2005.
Article
in English
| LILACS, Inca
| ID: lil-442296
ABSTRACT
Laryngeal cancer incidence in São Paulo, Brazil, is one of the highest in the world. OBJECTIVE:
This hospitalbasedcase-control study was designed to investigate exposure-disease relationship between larynx cancer andsmoking and drinking history, diet, occupational exposures and other characteristics. MATERIAL ANDMETHODS:
The study was conducted in 3 metropolitan areas in Brazil São Paulo (South-east), Curitiba (South)and Goiânia (Central-west). We have analyzed information on demographics, occupational history, environmental exposures, tobacco smoking and alcoholdrinking habits obtained from interviews with 194 cases and 804 controls (non-cancer inpatients) matched on 5-year age group, gender, hospital catchments area, and trimester of admission.RESULTS:
Tobacco and alcohol consumption were the most important factors for prediction of laryngeal cancer. Other important riskfactors were indoor exposure to wood stove fumes (RR=2.6), woodworking (RR=1.9), family history of cancer(RR=2.1), and high consumption of coffee and chimarrão(a kind of maté tea ). There was a protective effect for the consumption of citric fruits and forcarotene-rich vegetables.CONCLUSION:
regionally specific lifestyle (chimarrão, high consumption of woodworking, and family history of cancer may be responsible for a substantial proportion of incidentlaryngeal cancer cases.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Nicotiana
/
Laryngeal Neoplasms
/
Risk Factors
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2005
Type:
Article
Affiliation country:
Brazil
/
Canada
Institution/Affiliation country:
Hospital Araújo jorge/BR
/
Hospital Erasto Gaertner/BR
/
Hospital Heliópolis/BR
/
Hospital do Câncer A. C. Camargo/BR
/
McGill University/CA
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