Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy in the Treatment of Peritoneal Dissemination of Neoplasias: Preliminary Results with Closed Perfusion Technique
Appl. cancer res
;
25(2): 82-89, Apr.-June 2005.
Article
in English
| LILACS, Inca
| ID: lil-442300
ABSTRACT
OBJECTIVE:
to describe preliminary results ofcytoreductive surgery and intraperitoneal hyperthermicchemotherapy in the treatment of peritonealcarcinomatosis from a brazilian single institution.MATERIALS ANDMETHODS:
a short cohort study wascarried out. 26 patients and 28 procedures wereperformed consecutively between March 2001 and June2005. 17 patients (65.4%) were treated for pseudomyxomaperitonei, 4 patients had mesothelioma, 2 carcinomatosisfrom colorectal cancer origin, 2 from ovary cancer and 1had peritoneal sarcomatosis. All cases were treated withclosed perfusion technique. The Completeness ofCytoreduction Score was used to classify the radicalityof the procedure and the NIH Commom Toxicity Criteriawas used to classify the complications.RESULTS:
CC0and CC1 resections were achieved in 24 cases (85.7%).Grade 3 or 4 toxicity were observed in 5 cases (17.8%)and two patients died (7.1%). Severe complications weresignificant associated with the duration of surgery (morethan 10 hours).CONCLUSION:
this radical treatment ofperitoneal carcinomatosis envolves high morbidity andmortality rates and must be conducted in referral centerswith multiprofessional teams and carefully selection ofpatients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peritoneal Neoplasms
/
Drug Therapy
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital do Câncer A. C. Camargo/BR
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