Biochemical Relapse for Prostate Cancer Following Radical Prostatectomy: Salvage Radiotherapy Without HormonalTherapy
Appl. cancer res
; 26(1): 34-39, Jan.-Mar. 2006.
Article
in En
| LILACS, Inca
| ID: lil-442322
Responsible library:
BR30.1
ABSTRACT
Objectives:
This paper aims to study biochemical control, hormonal therapy-free survival, and prognostic factors related tosalvage radiation for prostate cancer patients submitted to radical prostatectomy (RP) without hormonal therapy (HT) before orduring radiation. Materials andMethods:
from August 2002 to July 2004, 39 prostate cancer patients submitted to RPpresented biochemical failure after achieving PSA nadir (<0.2ng/ml). All patients were submitted to three-dimensional conformalexternal beam radiation therapy (3DC-EBRT) and no patients had received HT. Median age was 62 years, median preoperativePSA was 9.4ng/ml, median Gleason Score was 7. We defined PSA rise above 0.2 as biochemical failure after surgery. Median3DC-EBRT dose was 70Gy, and biochemical failure after EBRT was defined as three consecutive rises in PSA or a single risesufficient to trigger HT.Results:
Biochemical non-evidence of disease (BNED) in 3 years was 72%. PSA doubling time (PSADT)lower than 4 months (p=0.04), and delay to salvage EBRT (p=0.05) were associated to worse chance of successful salvagetherapy. Late morbidity was acceptable.Conclusion:
Expressive PSA control (72% BNED / 3years) could be achieved withsalvage radiotherapy in well-selected patients. The importance of PSADT was confirmed, and radiotherapy should be started asearly as possible. Follow-up is somewhat short, but it is possible to conclude that it is possible to achieve a long interval freefrom hormonal therapy with low rate of toxicity, avoiding or at least delaying morbidity related to hormonal treatment.radiotherapy
Full text:
1
Index:
LILACS
Main subject:
Prostatectomy
/
Prostatic Neoplasms
/
Radiotherapy
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Appl. cancer res
/
Applied Cancer Research (Online)
/
Applied cancer research (Impresso)
Journal subject:
NEOPLASIAS
Year:
2006
Type:
Article