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Cien años de la enfermedad de Alzheimer: La inmunoterapia ¿una esperanza? / One hundred years of Alzheimer's disease: Immunotherapy a hope?
Behrens P., María Isabel; Vergara E., Fernando.
  • Behrens P., María Isabel; Universidad de Chile. Hospital Clínico. Departamento de Neurología y Neurocirugía. Santiago. CL
  • Vergara E., Fernando; Universidad de Los Andes. Los Andes. CL
Rev. méd. Chile ; 135(1): 103-110, ene. 2007. ilus
Article in Spanish | LILACS | ID: lil-443008
ABSTRACT
In 1906 Alois Alzheimer, described the cerebral lesions characteristic of the disorder that received his name senile plaques and neurofibrillary tangles. Alzheimer's disease (AD) is now, 100 years after, the most prevalent form of dementia in the world. The longer life expectancy and aging of the population renders it as a serious public health problem of the future. Urgent methods of diagnosis and treatment are required, since the definitive diagnosis of AD continues to be neuropathologic. In the last 30 years several drugs have been approved to retard the progression of the disease; however, there are still no curative or preventive treatments. Although still in experimentation, the visualization of amyloid deposition by positron emission tomography or magnetic resonance imaging will allow in vivo diagnosis of AD. In addition, experiments with the amyloid vaccine are still ongoing, and very recent data suggest that intravenous gammaglobulins may be beneficial and safe for the treatment of AD.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / Amyloid beta-Peptides / Alzheimer Vaccines / Alzheimer Disease / Immunotherapy Type of study: Diagnostic study Limits: Animals / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2007 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL / Universidad de Los Andes/CL

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Full text: Available Index: LILACS (Americas) Main subject: Peptide Fragments / Amyloid beta-Peptides / Alzheimer Vaccines / Alzheimer Disease / Immunotherapy Type of study: Diagnostic study Limits: Animals / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2007 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL / Universidad de Los Andes/CL