Estatus inmunológico de las madres infectadas por T. cruzi / Immunological status of mothers infected with Trypanosoma cruzi
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 101-104, 2005. graf
Article
in Spanish
| LILACS
| ID: lil-444165
ABSTRACT
The mechanisms of congenital transmission of Chagas disease remain largely unknown. To better understand the role of maternal immunology during pregnancy in congenital Chagas transmission, we studied the cytokine production and the parasitic load in three groups of mothers infected mothers who transmitted the disease to their babies (M+B+-), infected mothers who did not transmit the disease to their babies (M+B-) and not infected mothers as a control group (M-B-). M+B+ mothers produced less IFNgamma and more IL-10 than the M+B- mothers, and they are not able to produce IL-2. M+B+ mothers showed a higher parasitic load. These results, indicated that the congenital Chagas transmission is associated with an immunological imbalance and a high parasitic load in the M+B+ mothers.
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Index:
LILACS (Americas)
Main subject:
Pregnancy Complications, Infectious
/
Trypanosoma cruzi
/
Cytokines
/
Chagas Disease
/
Infectious Disease Transmission, Vertical
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
Spanish
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2005
Type:
Article
/
Congress and conference
Affiliation country:
Belgium
/
Bolivia
Institution/Affiliation country:
Universidad Mayor de San Simón (UMSS)/BO
/
Université Livre de Bruxelles/BE
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