Componentes celulares y fosfatasa alcalina placentaria en la infección por T. cruzi / Cellular components and placental alkaline phosphatase in Trypanosoma cruzi infection
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 87-91, 2005. graf, ilus
Article
in Spanish
| LILACS
| ID: lil-444167
ABSTRACT
Trypanosoma cruzi induces changes in the protein pattern of human placenta syncytiotrophoblast. Placental alkaline phosphatase (PLAP) is a glycoenzyme anchored to the membrane by a glycosyl-phosphatidylinositol molecule. PLAP activity and its presence was altered by the parasite in cultures of human placental villi and HEp2 cells with T.cruzi. The cells treated before the cultures with agents which affect PILAP or glycosyl-phosphatidylinositol (antibodies, PL-C, genistein, lithium) presented less parasitic invasion than the control ones. It was also observed a modification in the pattern of actine filaments of the host cells infected. We concluded that PLAP would participate in the process of T. cruzi invasion into placental syncitiotrophoblast cells, by a mechanism that involves hydrolysis of the glycosyl-phosphatidylinositol molecules, the activation of tyrosine kinase proteins, the increase of cytosolic calcium and the rearrangement of actine filaments of the host cells.
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Index:
LILACS (Americas)
Main subject:
Placenta
/
Trypanosoma cruzi
/
Chagas Disease
/
Alkaline Phosphatase
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
Spanish
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2005
Type:
Article
/
Congress and conference
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Córdoba/AR
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