Los fectos humanos estan capaces de generar una respuesta inmune T CD8 similar a la de los adultos / The human fetuses are be able to develep an adult-like immune CD8 T-cell response
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 92-95, 2005. tab, graf
Article
in Spanish
| LILACS
| ID: lil-444168
ABSTRACT
Fetal/Neonatal immune responses are generally considered to be immature and weaker than in adults. We have sudied the cord blood T-cells of newborns congenitally-infected whith Tripanosoma cruzi, the protozoan agent of Chagas' disease. Our data demonstrate a predominant activation of CD8 T-cells expressing activation markers and armed to mediate effector functions. Indeed, we have detected parasite-specific CD8 T-cells secreting interferon-ã. Such response is enchanced in the presence of rIL-15. These findings point out that the fetal immune system is more competent than previously appreciated, since fetuses exposed to live pathogens are able to develop an adult-like immune CD8 T-cell response.
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Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Fetus
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2005
Type:
Article
/
Congress and conference
Affiliation country:
Belgium
/
Bolivia
/
France
Institution/Affiliation country:
Institut Pasteur/FR
/
ULB/BE
/
Universidad Mayor de San Simón (UMSS)/BO
/
Université Livre de Bruxelles/BE
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