Enfermedad de Chagas congenita en Córdoba, Argentina: aspectos epidemiológicos, clínicos, diagnósticos y terapéuticos. Experiencia de 30 años de seguimiento / Congenital Chagas disease in Córdoba, Argentina: epidemiological, clinical, diagnostic, and therapeutic aspects. Experience of 30 years of follow up
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 33-40, 2005. tab, graf, ilus
Article
in Spanish
| LILACS
| ID: lil-444180
ABSTRACT
Chagas'disease has a great epidemiological relevance. Most of infected children are asymptomatics, with low mortality rate. The most frequent clinical findings are hepatomegaly and splenomegaly Parasitological methods: fresh smears, microStrout and Hemoculture, sequentially performed, detect the parasite in almost 100% of infected children. The gold standard for immunodiagnosis are serological curves, due to the interference of maternal IgG. Infected children maintain their antibody levels , whereas non infected became negatives. IgM test show false positive and false negative results. In children acutely infected during the first year of life and in cases of congenital infection, we observed high serum levels of soluble receptors of TNFalpha, IL-2 and sCD8, with significantly post treatment decrease. In a prospective 30 years research, we observed high therapeutic efficacy when children were treated before 3 years of life with benznidazol or nifurtimox, with good clinical evolution, together with parasitological and serological negativization.
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Index:
LILACS (Americas)
Main subject:
Chagas Disease
/
Pregnancy Complications, Parasitic
/
Infectious Disease Transmission, Vertical
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
South America
/
Argentina
Language:
Spanish
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2005
Type:
Article
/
Congress and conference
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Universitario de Maternidad y Neonatología/AR
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