Portación nasal de Streptococcus pneumoniae en adulto mayor y su respuesta frente a la vacunación antineumocócica / Nasal carriage of Streptococcus pneumoniae in elderly subjects according to vaccination status
Rev. méd. Chile
;
135(2): 160-166, feb. 2007. graf
Article
in Spanish
| LILACS
| ID: lil-445054
ABSTRACT
Background:
S pneumoniae is the main cause of community-acquired pneumonia in the elderly, group that concentrates 95 percent of deaths.Aim:
To assess the prevalence of nasal carriage of S pneumoniae in institutionalized elderly patients. Material andmethods:
One hundred eighteen institutionalized subjects aged over 60 years (65 males) were enrolled. Since they were also participating in a controlled protocol related to the immunogenicity of an anti-pneumococcal vaccine, our investigation was also blind and randomized. According to randomization, they received pneumococcal or tetanic vaccine. Nasal swab cultures were taken at the beginning of the trial and two months after vaccination. According to recommended methods, we identified S pneumoniae, the serotypes and their antimicrobial susceptibility.Results:
In the first nasal sample, 16 percent of subjects were positive for S pneumoniae. The second sample was positive in 12 percent. Of the 33 isolated serotypes, 9.1 percent demonstrated intermediate resistance to penicillin and 3.3 percent were resistant to chloramphenicol.Conclusions:
The study demonstrated a greater percentage of colonized patients than in the general population. The isolated serotypes are the same that cause invasive diseases in this age group, according to data of the Institute of Public Health of Chile. There were no differences in the percentage of colonization between subjects vaccinated against S pneumoniae and control groups, after two months of follow up. Isolated strains had a low resistance to penicillin. High level resistance was not observed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Streptococcus pneumoniae
/
Carrier State
/
Nasopharynx
/
Pneumococcal Vaccines
/
Anti-Bacterial Agents
Type of study:
Controlled clinical trial
/
Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2007
Type:
Article
Affiliation country:
Chile
/
Colombia
Institution/Affiliation country:
Universidad de Chile/CL
/
Universidad de la Frontera/CL
/
Universidad de los Andes/CO
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