Therapeutic targets in Paracoccidioides brasiliensis: post-transcriptome perspectives
Genet. mol. res. (Online)
;
4(2): 430-449, 30 jun. 2005. tab, ilus
Article
in English
| LILACS
| ID: lil-445278
ABSTRACT
The rise in antifungal resistance, observed as a result of the increasing numbers of immunocompromised patients, has made the discovery of new targets for drug therapy imperative. The description of the Paracoccidioides brasiliensis transcriptome has allowed us to find alternatives to refine current therapy against paracoccidioidomycosis. We used comparative analysis of expressed sequence tags to find promising drug targets that have been addressed in other pathogens. We divided the analysis into six different categories, based on the involvement of the targeted mechanisms in the cell i) cell wall construction, ii) plasma membrane composition, iii) cellular machinery, iv) cellular metabolism, v) signaling pathways, and vi) other essential processes. Through this approach, it has been possible to infer strategies to develop alternative drugs against this pathogen.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Paracoccidioides
/
Transcription, Genetic
/
Drug Design
/
Expressed Sequence Tags
/
Antifungal Agents
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2005
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Goiás/BR
/
Universidade de Brasília/BR
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