CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
Genet. mol. biol
;
30(1): 1-5, 2007. tab
Article
in English
| LILACS
| ID: lil-445674
ABSTRACT
The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.
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Index:
LILACS (Americas)
Main subject:
Steroid 17-alpha-Hydroxylase
/
Cytochrome P-450 CYP1A1
/
Cytochrome P-450 CYP2E1
/
Cytochromes a1
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Escola Nacional de Saúde Pública/BR
/
Instituto Oswaldo Cruz/BR
/
Universidade Federal do Rio Grande do Sul/BR
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