Increased urinary n-acetyl-beta-d-glucosaminidase activity in children with hydronephrosis
Int. braz. j. urol
;
33(1): 80-86, Jan.-Feb. 2007. tab
Article
in English
| LILACS
| ID: lil-447472
ABSTRACT
OBJECTIVE:
Hydronephrosis leads to deterioration of renal function. As urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity is considered a sensitive marker of renal tubular impairment, our aim was to measure U-NAG in children with hydronephrosis and to look for a relationship among selected clinical parameters. MATERIALS ANDMETHODS:
We studied 31 children (22 boys and 9 girls, mean age 2.3 ± 2.5 years) with hydronephrosis grade 1-4 that had U-NAG/creatinine ratio (U-NAG/Cr) measured.RESULTS:
The U-NAG/Cr was significantly higher in patients with hydronephrosis compared to reference data (p = 0.002). There was no difference in U-NAG/Cr between children with unilateral and bilateral hydronephrosis (p = 0.51). There was no significant difference in U-NAG/Cr between children with grades 1-3 (pooled data) and grade 4, respectively (p = 0.89). There was no correlation between U-NAG/Cr and the grade of hydronephrosis (r = 0.01).CONCLUSIONS:
U-NAG/Cr is increased in children with hydronephrosis grade 1-4, and there is no relationship with the grade of hydronephrosis. U-NAG is a useful marker of renal tubular dysfunction, however its relationship with the degree of kidney damage in patients with hydronephrosis should be considered as doubtful.
Full text:
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Index:
LILACS (Americas)
Main subject:
Acetylglucosaminidase
/
Hydronephrosis
/
Kidney Tubules
Limits:
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2007
Type:
Article
Affiliation country:
Czech Republic
Institution/Affiliation country:
Charles University in Prague/CZ
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