Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model
Biocell
;
30(1): 9-13, abr. 2006. ilus, tab
Article
in English
| LILACS
| ID: lil-448072
ABSTRACT
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations
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Index:
LILACS (Americas)
Main subject:
Podophyllotoxin
/
Onions
/
Cytotoxins
/
Calotropis
/
Latex
Language:
English
Journal:
Biocell
Journal subject:
Clulas
Year:
2006
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
All India Institute of Medical Sciences/IN
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