Contribuição do estudo molecular de hemoglobinas S-like para o conhecimento da diversidade genética da população brasileira: [carta ao editor] / The contribution of molecular studies of S-like hemoglobins to knowledge of the genetic diversity of the Brazilian population: [letter to editor]

ABSTRACT

Over 900 hemoglobin variants have already been described, withmore than 100 having electrophoretic migration similar to Hb S inalkaline pHs. In the analysis of 98 samples that presented with thismigration pattern, Hb D-Los Angeles in heterozygosis was prevalentand associations with Hb S and Hb Lepore were identified, apreviously unpublished fact and with beta-thalassemia, which isalso rare. In addition, carriers of Hb Korle-Bu and Hb Hasharonwere found amongst other hemoglobinopathies. This heterogeneityreflects the special colonization conditions and the high racialadmixture in Brazil. The correct laboratorial diagnosis is veryimportant for hemoglobinopathy carriers because of the manyassociations of hemoglobin alterations and the variants with comigration.An accurate identification of hemoglobin variants isessential for genetic counseling and appropriate therapy.