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Identification in silico of putative damage responsive elements (DRE) in promoter regions of the yeast genome
Silva, Walkiria Luckwu de Santana; Cavalcanti, Andre Ricardo de Oliveira; Guimarães, Katia Silva; Morais Júnior, Marcos Antonio de.
  • Silva, Walkiria Luckwu de Santana; Universidade Federal de Pernambuco. Centro de Informática. Laboratório de Bioinformática. Recife. BR
  • Cavalcanti, Andre Ricardo de Oliveira; Universidade Federal de Pernambuco. Centro de Ciências Exatas e da Natureza. Departamento de Química Fundamental. Recife. BR
  • Guimarães, Katia Silva; Universidade Federal de Pernambuco. Centro de Informática. Laboratório de Bioinformática. Recife. BR
  • Morais Júnior, Marcos Antonio de; Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Genética. Recife. BR
Genet. mol. biol ; 28(4): 814-820, Dec. 2005. tab, graf
Article in English | LILACS | ID: lil-450993
ABSTRACT
We report an in silico analysis to identify nucleotide sequence motifs in DNA repair genes that may define a binding site for regulatory proteins during the induction of those genes by mutagens. The damage responsive elements (DRE) weight matrix generated in this analysis was used to search for homologous sequences in the promoter region of all genes, including putative gene and hypothetical open reading frames (ORFs), in the Saccharomyces Genome Data Base (SGD). The results demonstrated that over one third of the yeast genes in the database presented at least one 15-bp sequence in their promoter region with 85% or more of similarity to the DRE consensus sequence. The presence of the DRE sequence in the promoter region of regulatory genes and its high similarity to other well reported DNA binding sites points to its involvement in the general regulation of not only DNA repair genes but yeast genes in general
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Yeasts / DNA Damage Type of study: Diagnostic study Limits: Animals Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Yeasts / DNA Damage Type of study: Diagnostic study Limits: Animals Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR