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Genotoxic evaluation of sodium nitroprusside in Aspergillus nidulans
Chiuchetta, Simone Jurema Ruggeri; Castro-Prado, Marialba Avezum Alves de.
  • Chiuchetta, Simone Jurema Ruggeri; Universidade Estadual de Maringá. Departamento de Biologia Celular e Genética. Maringá. BR
  • Castro-Prado, Marialba Avezum Alves de; Universidade Estadual de Maringá. Departamento de Biologia Celular e Genética. Maringá. BR
Genet. mol. biol ; 28(4): 798-803, Dec. 2005. ilus, tab, graf
Article in English | LILACS | ID: lil-450995
ABSTRACT
The exogenous nitric oxide donor, sodium nitroprusside, evaluated the recombinogenic potential of nitric oxide. Drug inhibited mycelial growth and conidiation in A757 Aspergillus nidulans master strain. Two heterozygous diploid strains, one wild (uvsH+//uvsH+) and the other defective to DNA repair (uvsH//uvsH) were used for recombinagenesis tests. Sodium nitroprusside recombinogenic effect was evaluated by the induction of homozygosis of recessive genes, originally present in heterozygous condition. Results show that sodium nitroprusside (40 uM, 80 uM and 160 uM) is effective in inducing mitotic crossing-over in diploid cells of A. nidulans
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Full text: Available Index: LILACS (Americas) Main subject: Aspergillus nidulans / Nitric Oxide Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR

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Full text: Available Index: LILACS (Americas) Main subject: Aspergillus nidulans / Nitric Oxide Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2005 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Maringá/BR