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Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Sowunmi, Akintunde; Gbotosho, Grace O; Happi, Christian T; Adedeji, Ahmed A; Bolaji, Olayinka M; Fehintola, Fatai A; Fateye, Babasola A; Oduola, Ayoade M. J.
Affiliation
  • Sowunmi, Akintunde; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Gbotosho, Grace O; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Happi, Christian T; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Adedeji, Ahmed A; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Bolaji, Olayinka M; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Fehintola, Fatai A; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Fateye, Babasola A; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
  • Oduola, Ayoade M. J; University of Ibadan. Institute for Medical Research and Training. Department of Pharmacology and Therapeutics. Ibadan. NG
Mem. Inst. Oswaldo Cruz ; 102(3): 417-420, June 2007. tab
Article in En | LILACS | ID: lil-452507
Responsible library: BR1.1
ABSTRACT
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.
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Full text: 1 Index: LILACS Main subject: Membrane Transport Proteins / Protozoan Proteins / Chloroquine / Chlorpheniramine / Malaria, Falciparum / Amodiaquine / Histamine H1 Antagonists / Antimalarials Limits: Animals / Humans Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2007 Type: Article
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Full text: 1 Index: LILACS Main subject: Membrane Transport Proteins / Protozoan Proteins / Chloroquine / Chlorpheniramine / Malaria, Falciparum / Amodiaquine / Histamine H1 Antagonists / Antimalarials Limits: Animals / Humans Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2007 Type: Article