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Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency
Yan, Jian; Jiao, Yan; Li, Xinmin; Jiao, Feng; Beamer, Wesley G; Rosen, Cliff J; Gu, Weikuan.
  • Yan, Jian; University of Memphis. Department of Biology. Memphis. US
  • Jiao, Yan; University of Tennessee Health Science Center. Department of Orthopedic Surgery-Campbell Clinic. Center of Genomics and Bioinformatics. Center of Diseases of Connective Tissues. Memphis. US
  • Li, Xinmin; University of Chicago. Functional Genomics Facility. Chicago. US
  • Jiao, Feng; University of Tennessee Health Science Center. Department of Orthopedic Surgery-Campbell Clinic. Center of Genomics and Bioinformatics. Center of Diseases of Connective Tissues. Memphis. US
  • Beamer, Wesley G; The Jackson Laboratory. Bar Harbor. US
  • Rosen, Cliff J; The Jackson Laboratory. Bar Harbor. US
  • Gu, Weikuan; University of Tennessee Health Science Center. Department of Orthopedic Surgery-Campbell Clinic. Center of Genomics and Bioinformatics. Center of Diseases of Connective Tissues. Memphis. US
Genet. mol. biol ; 30(2): 322-329, Mar. 2007. tab, ilus, graf
Article in English | LILACS | ID: lil-452805
ABSTRACT
Humans and guinea pigs are species which are unable to synthesize ascorbic acid (vitamin C) because, unlike rodents, they lack the enzyme L-gulonolactone oxidase (Gulo). Although the phenotype of lacking vitamin C in humans, named scurvy, has long been well known, information on the impact of lacking Gulo on the gene expression profiles of different tissues is still missing. This knowledge could improve our understanding of molecular pathways in which Gulo may be involved. Recently, we discovered a deletion that includes all 12 exons in the gene for Gulo in the sfx mouse, characterized by spontaneous bone fractures. We report here the initial analysis of the impact of the Gulo gene deletion on the murine gene expression profiles in the liver, femur and kidney.
Full text: Available Index: LILACS (Americas) Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2007 Type: Article / Project document Affiliation country: United States Institution/Affiliation country: The Jackson Laboratory/US / University of Chicago/US / University of Memphis/US / University of Tennessee Health Science Center/US

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Full text: Available Index: LILACS (Americas) Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2007 Type: Article / Project document Affiliation country: United States Institution/Affiliation country: The Jackson Laboratory/US / University of Chicago/US / University of Memphis/US / University of Tennessee Health Science Center/US