Complete ¹H and 13C NMR assignments and anti fungal activity of two 8-hydroxy flavonoids in mixture
An. acad. bras. ciênc
;
79(2): 215-222, June 2007. tab, ilus
Article
in English
| LILACS
| ID: lil-454592
ABSTRACT
A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (¹HNMR, {¹H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete ¹H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated.
RESUMO
Os flavonóis 8-hidroxi-3, 4', 5, 6, 7-pentametoxiflavona (1) e 8-hidroxi-3, 3', 4', 5, 6, 7-hexametoxiflavona (2) foram isolados em mistura a partir de uma amostra comercial de Citrus aurantifolia. A determinação estrutural e a inequívoca atribuição dos sinais de deslocamento químico dos átomos de hidrogênio e carbono destes compostos naturais foram realizadas através da análise dos espectros de RMN 1D e 2D, incluindo COSY, NOESY, HMQC e HMBC. Em adição, a atividade antifúngica destes compostos contra fungos patogênicos também foiinvestigada.
Full text:
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Index:
LILACS (Americas)
Main subject:
Flavonoids
/
Magnetic Resonance Spectroscopy
/
Citrus aurantiifolia
/
Fungi
/
Antifungal Agents
Limits:
Humans
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Feira de Santana/BR
/
Universidade Estadual do Norte Fluminense/BR
/
Universidade Federal de Santa Catarina/BR
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