The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir
Braz. j. infect. dis
;
11(2): 212-214, Apr. 2007.
Article
in English
| LILACS
| ID: lil-454738
ABSTRACT
The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3 percent, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antiviral Agents
/
Ganciclovir
/
Lung Transplantation
/
Cytomegalovirus Infections
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Casa Complexo Hospitalar/BR
Similar
MEDLINE
...
LILACS
LIS